The Hidden Link Between Low Progesterone and Anxiety

Woman sits on bed while hugging her knees with a worried expression on her face, illustrating anxiety possibly linked to low progesterone.

If you’ve been living with anxiety, you know how exhausting it can be. The racing thoughts, the constant worry, the feeling like you’re barely keeping your head above water – it’s overwhelming.

You’ve probably tried everything: meditation apps, breathing exercises, maybe even therapy or medication. And while these can help, what if I told you that your anxiety might have a deeper root cause that no one has talked to you about?

You’re not broken. You’re not weak. And you’re definitely not imagining things. What you might be experiencing is a hormonal imbalance that affects millions of women – and the good news is, it’s treatable.

What Is Progesterone?

Progesterone is often called the “calming hormone” for good reason. Produced primarily after ovulation, it acts as your body’s natural anti-anxiety medication. Think of it as your internal stress-relief system – when progesterone levels are optimal, you feel grounded, peaceful, and resilient to stress.

But when progesterone is low, anxiety often takes center stage.

How Progesterone Calms Anxiety

Progesterone works its magic through several pathways:

GABA Production: Progesterone increases GABA, your brain’s primary “calm down” neurotransmitter. GABA helps quiet racing thoughts and promotes relaxation. When progesterone is low, the body cannot produce GABA and we do not feel calm.

Cortisol Balance: Progesterone helps regulate cortisol, your stress hormone. Without enough progesterone, cortisol can run unchecked, leaving you feeling wired and anxious.

Sleep Support: Progesterone has a sedating effect that promotes deep, restorative sleep. Poor sleep and anxiety create a vicious cycle – anxiety disrupts sleep, and sleep deprivation worsens anxiety.

Signs Your Anxiety Might Be Progesterone-Related

  • Anxiety that worsens in the week before your period
  • Feeling calm during the first half of your cycle, then anxious during the second half
  • Racing thoughts, especially at bedtime
  • Difficulty falling or staying asleep
  • Feeling “wired but tired”
  • Increased sensitivity to stress
  • Panic attacks that seem to come out of nowhere
  • PMS symptoms alongside anxiety

What Causes Low Progesterone?

Several factors can deplete progesterone levels:

Chronic Stress: Your body prioritizes cortisol production over progesterone when you’re stressed, a phenomenon called “progesterone steal.”

Anovulatory Cycles: If you’re not ovulating regularly, you’re not producing adequate progesterone.

Age: Progesterone naturally declines with age, especially during perimenopause.

Poor Sleep: Your body produces progesterone during deep sleep phases.

Nutrient Deficiencies: Low zinc, magnesium, and B vitamins can impair progesterone production.

These kinds of deficiencies often contribute to long-term patterns of illness. Learn more on the Chronic Illness page.

A person's hands preparing fresh salad packed with organic ingredients such as leafy greens, tomatoes, cucumbers. This highlights the importance of magnesium-rich and nutrient-dense food that contribute to healthy progesterone levels, thereby helping to alleviate anxiety.

Supporting Progesterone Naturally

Manage Stress: Practice stress-reduction techniques like deep breathing, meditation, or gentle yoga to prevent progesterone steal.

Prioritize Sleep: Aim for 7-9 hours of quality sleep. Create a calming bedtime routine and keep your bedroom cool and dark.

Eat Progesterone-Supporting Foods:

  • Zinc-rich foods: pumpkin seeds, grass-fed beef, chickpeas
  • Magnesium sources: dark leafy greens, avocados, dark chocolate
  • B vitamins: nutritional yeast, eggs, wild-caught fish

Support Ovulation: Regular ovulation is essential for progesterone production. Maintain stable blood sugar, eat adequate calories, and consider tracking your cycle.

Limit Alcohol and Caffeine: Both can interfere with sleep quality and hormone production.

Many women also discover that gut health plays a key role in hormone balance. See how the two connect on the Gut Health & Mood Disorders page.

When to Seek Help

If you’re experiencing persistent anxiety along with irregular periods, severe PMS, or sleep issues, it’s worth getting your hormones tested. A healthcare provider can measure your progesterone levels and help determine if hormone imbalance is contributing to your anxiety.

For a step-by-step approach to uncovering hidden imbalances like these, explore the RESTORE™ Protocol.

Remember: progesterone deficiency is common and treatable. You don’t have to accept anxiety as “just how you are.”

If your symptoms don’t match your thyroid labs, explore why this happens on the Thyroid Imbalances page.

Your Path to Healing

Your anxiety might not be “all in your head” – it could be in your hormones. Understanding the progesterone-anxiety connection empowers you to address the root cause rather than just managing symptoms. By supporting healthy progesterone levels through lifestyle changes, many women find their anxiety naturally decreases.

If you’ve been struggling with unexplained anxiety, especially if it follows a monthly pattern, consider looking at your progesterone levels. Your calmer, more balanced self might be just a hormone away.

Ready to start supporting your progesterone naturally? Download my free collection of 15 Progesterone-Supporting Recipes – delicious meals packed with the nutrients your body needs to produce this calming hormone and reduce anxiety.

Meet Jess

Hi there, I’m Jess Sorci, Certified Nutrition Specialist and Functional Medicine Practitioner. I help people with chronic illness and autoimmune conditions uncover the root causes of their symptoms and heal the whole person, body and mind. My approach weaves together functional medicine, nutrition, lab testing, and grief-informed care.

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About Jess Sorci

Jess Sorci, MS, CNS®, LDN, is a Certified Nutrition Specialist® and Functional Medicine Practitioner with over a decade of clinical experience. She specializes in chronic illness, autoimmune conditions, and grief-informed care, combining advanced lab testing, nutrition, and compassionate coaching to uncover root causes and restore balance.

When she’s not not working in her practice, Jess can be found biking, hiking, and camping with her husband Nathan and their two chocolate labs.

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